ABSTRACT
Objective To explore the transmission pattern of corona virus disease 2019 (COVID-19) in the population by describing an imported case of novel coronavirus infected pneumonia epidemic situation. Methods Using the method of field investigation, epidemiological investigations were carried out for the imported COVID-19 case and the close contacts related to this epidemic cluster.Data were collected concerning the date of onset, isolation of the case and close contacts.The novel coronavirus nucleic acid was collected from the throat swabs of the case and close contacts.These samples were detected by real-time fluorescence quantitative RT-PCR. Results In this epidemic cluster, there was one confirmed case, that had been exposed to 36 people (12 in the family and 24 outside the family) and 2 in the family were nucleic acid positive and diagnosed as asymptomatic infections. Conclusion COVID-19 transmission proves to be mainly through respiratory droplets and close contact, which easily causes family aggregation epidemic.
ABSTRACT
Objective To observe the protective effect of propofol on hematopoietic system injury in mice with total body irradiation (TBI). Method Three different radiation doses were used in the experiments: 7.5 Gy TBI in 30 day-survival experiment, 6Gy TBI in colony-forming unit spleen (CFU-S) experiment and 2Gy TBI in the other experiment; mice were divided into 4 groups in a 30 day-survival experiment, including 7.5Gy TBI group, 7.5 Gy TBI + 5 mg/kg propofol group, 7.5 Gy TBI + 10 mg/kg propofol group and 7.5 Gy TBI + 20 mg/kg propofol group. For the other experiments, mice were divided into 4 groups: control group, propofol group, TBI (2 or 6 Gy) group, and TBI + 20 mg/kg propofol group. Propofol of 20 mg/kg were administered to mice 1 d before TBI, 30 mins before TBI and once each day within the following 7 days after TBI. Mice were euthanized on the ninth day after TBI, the number of CFU-S, peripheral blood parameters and bone marrow cells per femur were measured in this experiment. Results Propofol improved the 30 day-survival of lethally irradiated mice. There were increases in number of CFU-S, white blood cells, red blood cells, hemoglobin in peripheral blood and bone marrow cells per femur in 2 Gy TBI + 20 mg/kg propofol group compared to 2 Gy TBI group (P<0.05). Conclusion Propofol exhibits a promising protective effect on TBI-induced hematopoietic system injury; further study should be focused on the related mechanisms.